Running (from) Depression: a Controlled study vs. Sertraline

What is that is going on (in) here, psychoanalytically: Lower remission rate with excercise vs. Sertraline. We have more to learn about this thing called “depression.”

NSzajnberg, MD Managing Editor

Dr. Noordsy referenced a study from researchers at Duke University in which 156 patients with major depressive disorder (MDD) were randomly assigned either to aerobic exercise, sertraline therapy (50 mg to 200 mg), or both for 4 months.

The difference in remission rates in the exercise and selective serotonin reuptake inhibitor (SSRI) groups after 4 months were not significant – 60% and 69%, respectively, but at a 10-month follow-up, the exercise group showed a significantly lower relapse rate ( P = .01) ( Psychosom Med 2000;62:633-638).

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