IPBooks is pleased to announce the publication of: Fibrinogen Memoirs 2: The Rise and Fall of the Fibrin Cross-linking Controversy. by Michael W. Mosesson
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The Rise and Fall of the Fibrin Cross-linking Controversy concerns the longstanding controversy over the arrangement of ‘cross-linked’ structures within fibrin clots. The narrative covers the period from its origins to its unexpected decline and demise. The decades-long unresolved dispute over whether the cross-links were arranged in a ‘longitudinal’ or a ‘transverse’ position was replaced by the dogma that they were ‘longitudinal’, a structural arrangement that could not account for fibrin’s known elastic properties. The alternative bond arrangement, transverse, was no longer mentioned, despite an overwhelming body of evidence for its existence. This realization, coupled with the understanding that only a transverse bond arrangement Continue reading Fibrinogen Memoirs 2: The Rise and Fall of the Fibrin Cross-linking Controversy by Michael W. Mosesson